Avène Cleanance Comedomed Anti-imperfection Concentrate. Pioneering treatment for oily skin, reduces visible and invisible imperfections and limits their reappearance thanks to Comedoclastin™*, a plant-origin extract, and Avène thermal spring water. Since 1990, Eau Thermale Avène has been committed to advancing dermatology and improving the quality of life for people with sensitive skin. At the heart of our brand is Avène spring thermal water, a unique active ingredient that provides scientifically proven relief. Developed in collaboration with healthcare professionals and inspired by nature, our skincare solutions reflect a shared mission: to care for sensitive skin while respecting its origin. This same vision also lives through our Cleanance range. For over 30 years, we have been committed to helping oily and blemish-prone skin with highly tolerant skincare. Cleanance products purify, protect, and beautify the skin of teenagers and young adults, either alone or as a complement to prescribed treatments. Don’t give up, Cleanance is your best ally in this fight Looking for a solution to reduce blemishes and prevent their reappearance? Eau Thermale Avène Cleanance Comedomed, enriched with Comedoclastin™* and Avène spring thermal water, is clinically proven to reduce visible and invisible blemishes from 7 days* and helps prevent their reappearance. *Registered patent. **International clinical observational study, 90% of individuals without blemish reappearance at 6 months. ***Tolerance and efficacy study under dermatological control on 51 participants, use of Cleanance Comedomed twice daily for 56 days. -Acts on blemishes and reduces their reappearance: Cleanance Comedomed is an innovative product for oily skin with blemishes. It reduces spots and prevents their reappearance. Suitable for adults, teenagers, and pregnant women. -Formulated with Comedoclastin™*: Its non-comedogenic, fragrance-free, and highly tolerant formula combines Comedoclastin™*, a plant-based active ingredient, with Avène spring thermal water for clearer, more even, and comfortable skin. -Visible results in 7 days: This facial cream is clinically proven to reduce blemishes in 7 days* and helps prevent their reappearance. Its light, non-greasy texture is quickly absorbed, leaving the skin hydrated and matte. -Anti-spot routine: Morning and night on clean, dry skin. Apply dabs on the T-zone and cheeks, then make circular movements. Apply on cheeks and lower facial area. Use alone or after acne treatments (except oral isotretinoin). -When science merges with nature: Eau Thermale Avène combines dermatological science with the soothing power of Avène spring thermal water, sourced from a unique natural site and enriched over 50 years. Apply twice a day on the face. Rub the T-zone and cheeks, massage in circles, smooth on the lower part. Store in a cool, dry place away from direct sunlight.